Monatshefte fur Chemie p. 1245 - 1248 (2010)
Update date:2022-07-29
Topics:
Sabitha, Gowravaram
Nagendra Prasad
Ramesh
Yadav
Silica sulfuric acid was found to be an efficient catalyst for the vinylogous Mukaiyama aldol reaction of 2-(trimethylsilyloxy)furan with various aldehydes with good diastereoselection. The reaction proceeds rapidly in THF, affording the corresponding 5-(arylhydroxymethyl)furan-2(5H)-ones in good yields. This method offers significant advantages such as experimental simplicity, and recoverability and reusability of the catalyst.
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