TOTAL SYNTHESIS OF OPTICALLY ACTIVE MONOCROTALINE, A CARCINOGENIC PYRROLIZIDINE ALKALOID HAVING AN 11-MEMBERED DILACTONE

DOI: 10.1016/S0040-4039(00)80702-9

Source and publish data:

Tetrahedron Letters p. 5139 - 5142 (1988)

Update date:2022-07-30

Topics: Total synthesis Optically active Pyrrolizidine alkaloid

Authors:

Niwa, Haruki

Okamoto, Osamu

Yamada, Kiyoyuki

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Article abstract of DOI:10.1016/S0040-4039(00)80702-9

Monocrotaline (1), a representative of carcinogenic pyrrolizidine alkaloids with an 11-membered dilactone has been synthesized in optically active form by virtue of regioselective coupling of (+)-retronecine (2) and the protected necic acid 3, the latter being synthesized enantioselectively from the meso-diester 4.

Full text of DOI:10.1016/S0040-4039(00)80702-9

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