Tetrahedron Letters p. 5139 - 5142 (1988)
Update date:2022-07-30
Topics: Total synthesis Optically active Pyrrolizidine alkaloid
Niwa, Haruki
Okamoto, Osamu
Yamada, Kiyoyuki
Monocrotaline (1), a representative of carcinogenic pyrrolizidine alkaloids with an 11-membered dilactone has been synthesized in optically active form by virtue of regioselective coupling of (+)-retronecine (2) and the protected necic acid 3, the latter being synthesized enantioselectively from the meso-diester 4.
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