ENZYMATIC FORMATION OF AN ISOPEPTIDE BOND INVOLVING THE ε-AMINO GROUP OF LYSINE

DOI: 10.1016/S0040-4039(00)80793-5

Source and publish data:

Tetrahedron Letters p. 5487 - 5488 (1988)

Update date:2022-07-30

Topics:

Authors:

Kitaguchi, Hiroshi

Tai, Dar-Fu

Klibanov, Alexander M.

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Article abstract of DOI:10.1016/S0040-4039(00)80793-5

Bacterial protease and lipase act as regioselective preparative catalyst of peptide bond synthesis in anhydrous organic solvents: when a derivative of lysine is used as the amino component, only its ε-NH2 group reacts (to give an isopeptide linkage).

Full text of DOI:10.1016/S0040-4039(00)80793-5

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