A NEW ENTRY TO THE SYNTHESIS OF β-HYDROXYTYROSINES VIA A NOVEL BENZYLIC HYDROXYLATION

Article abstract of DOI:10.1016/S0040-4039(00)80712-1

Highly stereoselective introduction of a hydroxyl group into the benzylic position of N-tert-butoxycarbonyl-L-tyrosine derivatives was achieved by the use of K2S2O8/CuSO4 system to give the threo cyclic carbamates.These were converted into β-hydroxytyrosine and octopamine, efficiently.