2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms

DOI: 10.1021/jm00128a043

Source and publish data:

Journal of Medicinal Chemistry p. 1949 - 1958 (1989)

Update date:2022-08-03

Topics:

Authors:

Roth Roth

Tidwell Tidwell

Ferone Ferone

Baccanari

Sigel Sigel

DeAngelis

Elwell Elwell

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Article abstract of DOI:10.1021/jm00128a043

A series of 2,4-diamino-5-(3,5-dialkenyl-4-methoxy- or -4-hydroxybenzyl)pyrimidines was prepared from [(allyloxy)benzyl]pyrimidines by Claisen rearrangements, and the resulting allyl phenols were further modified by methylation and rearrangement to 1-prop

Full text of DOI:10.1021/jm00128a043

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