An efficient MnCl2-catalyzed tandem acylation-cross-coupling reaction of o-halobenzoyl chloride with diorganyl magnesium compounds

Article abstract of DOI:10.1002/aoc.1567

An efficient tandem cross-coupling reaction of o-chlorobenzoyl chloride with dialkyl and diaryl magnesium compounds in the presence of manganese (II) chloride was developed, which proceeds in good yield under mild conditions. Copyright

Full text of DOI:10.1002/aoc.1567

Letter to the Editor
Received: 15 March 2009
Revised: 16 September 2009
Accepted: 16 September 2009
Published online in Wiley Interscience: 6 November 2009
(www.interscience.com) DOI 10.1002/aoc.1567
An efficient MnCl2-catalyzed tandem
acylation-cross-coupling reaction
of o-halobenzoyl chloride with diorganyl
magnesium compounds
Fengmin Zhang, Zhuangzhi Shi, Feng Chen and Yu Yuan∗
An efficient tandem cross-coupling reaction of o-chlorobenzoyl chloride with dialkyl and diaryl magnesium compounds in the
c
presence of manganese (II) chloride was developed, which proceeds in good yield under mild conditions. Copyright ꢀ 2009
John Wiley & Sons, Ltd.
Keywords: manganese; magnesium; tandem; coupling reaction; catalysis
Introduction
in certain cases due to the reductivity and nucleophilicity of
the organomagnesium reagents. Their exact formation can be
explained as follows: ketone 5 is the intermediate 4 (in Scheme 1)
which has failed to undergo the Kumada type coupling reaction;
alcohol 6 is the result of reduction of 5 which occurs by oxygen
complexation to an organomagnesium compound followed by
β-hydride elimination onto the carbonyl group;[29] 7 and 8 are the
products of addition of a second butyl group to 5 followed by
elimination. These side reactions led to only moderate yields
of the desired product 3a when Grignard reagent 2a and
tributylmagnesiate complex 2b were used.[30] The magnesium
cyanocuprate 2c merely underwent acylation in the presence
of the catalyst giving no other products. The dibutylmagnesium
2d reacted well with 1a, giving only small amounts of the by-
products, although all types were detected. The best result for
this reaction was obtained using the dibutylmagnesium lithium
chloride complex 2e. Lithium chloride has been shown to enhance
the reactivity of Grignard reagents (formed in situ in this case)
by breaking up RMgCl aggregates and thus forming RMgCl2Li
complexes with magnesiate character.[31–33]
To examine the substrate scope of this tandem cross-coupling
reaction, various halogen-substituted benzoyl chlorides were
reacted with 2e under the optimized conditions (Table 2). It was
found that iron (III) can also catalyze this type of reaction in good
yield, but the result is not better than that using manganese (II).
Interestingly, only ortho-substituted arenes underwent reaction,
with even the equally reactive para-substituted compound
resisting coupling. This indicates that some kind of intramolecular
coordination by the ketone is necessary for activation of
metal intermediates or reagents for the coupling reaction to
occur. It was also of interest that dichloride 1a was the best
The cross-coupling reaction of organometallic reagents with
organic electrophiles in the presence of a transition-metal catalyst
is a classical method of forming C–C bonds.[1,2] Since the discovery
of the Kumada coupling reaction,[3] many transition metals, such
as nickel, palladium,[4–8] iron[9–13] and copper,[14–17] have been
used to catalyze the reaction of organomagnesium compounds
with halides. Some examples employ manganese (II) as the
catalyst[18–25] and recently Cahiez found that organomanganese
reagents could be cross-coupled with ortho-acylated aryl chlorides
in good yields.[26] Recently we reported the homocoupling
reaction of halide compounds in one pot by a combination of
metallic magnesium and MnCl2.[27] Herein, we report an efficient
tandem cross-coupling reaction of o-chlorobenzoyl chloride with
dialkyl and diaryl magnesium compounds in the presence of
manganese (II) chloride.
Initial studies focused on the cross-coupling reaction of
dialkyl magnesium with aryl halides catalyzed by a transition
metal. Unfortunately, all attempts to perform this reaction
failed (Scheme 1). It was realized that the use of Grignard
reagents rather than dialkyl magnesium compounds is of utmost
importanceinmakingthiskindofcross-couplingreactionproceed.
We therefore proposed the tandem cross-coupling reaction of
dialkyl magnesium with o-halobenzoyl chloride 1, in which the
necessary Grignard reagents would be generated in situ from
acylation of the dialkyl magnesium 2 with o-halobenzoyl chloride
(Scheme 1). Cahiez reported the Mn-catalyzed acylation reaction
of organomagnesium reagents with acyl chloride,[28] which is
similar to this reaction. The resulting Grignard reagent would then
react immediately with the aryl halide 4 in the presence of the
catalyst. This would provide a one pot synthesis of substituted aryl
ketones.
∗
As shown in Table 1, various types of n-butylmagnesium
reagents 2 were tested (in quantities amounting to 2.6 eq. n-butyl
group) to optimize the reaction with o-chlorobenzoyl chloride
1a catalyzed by manganese (II) chloride. Alongside the expected
product 3a, some other compounds, 5–8, were also observed
Correspondence to: Yu Yuan, Yangzhou University, College of Chemistry and
Chemical Engineering, 225002 Yangzhou, Jiangsu Province, China.
E-mail: yyuan@yzu.edu.cn
College of Chemistry and Chemical Engineering, Yangzhou University, 225002
Yangzhou, People’s Republic of China
c
Appl. Organometal. Chem. 2010, 24, 57–63
Copyright ꢀ 2009 John Wiley & Sons, Ltd.

F. Zhang et al.
compounds with 1a, shown in Table 3, took place smoothly to
afford the corresponding products in good yields. It was found
that the reactions using higher dialkylmagnesium compounds
(2i, 2k, 2l) as substrates were better than that using using
diethylmagnesium, 2f, which demonstrates that the reductivity
and nucleophilicity of 2f is stronger than those of higher
dialkylmagnesiates, as noted previously in the literature,[34] and
lead more quickly to by-products. The best results were obtained
with the long-chain dialkylmagnesium compounds 2i and 2k.
More sterically hindered dicyclopentylmagnesium 2j gave a lower
yield (79%) than the open chain analog 2i (91%).
X
Bu
cat
n-Bu2Mg
+
cat = MnCl , FeCl , Fe(acac)
X = Cl, Br, I
2
3
3
O
O
catalyst
+
Cl
R2Mg
R
X
R
1
2
3
RMgX
Finally, we investigated the scope of diarylmagnesium–LiCl
complexes (prepared according to the literature[35]) compati-
ble with the MnCl2-catalyzed tandem cross-coupling reaction of
various o-halobenzoyl chlorides. (Table 4). In contrast with the
dialkylmagnesium compounds, the best yield, using diphenyl-
magnesium 2m, was obtained using iodo-arene 1c. Because of
the instability of 1c, the almost equally reactive bromo-arene 1b
was chosen as the substrate for testing the remaining diarylmag-
nesium compounds in the reaction. All revealed high reactivity
in giving products containing a biphenyl core – a structure found
widely in ligands and drugs.
O
R2Mg
catalyst
R
catalyst
X
4
Scheme 1. Possible reaction path of the aryl halides with dialkyl
magnesium.
Table 1. Mn(II)-catalyzed cross-coupling reaction between o-
chlorobenzoyl chloride and different organometallic reagentsa
Conclusion
O
Cl
O
n-Bu
n-Bu
n-BunMX,10 mol% MnCl2
+
Cl
In summary, we have developed a one-pot synthesis of (ortho-
organyl)aryl organyl ketones, in which the organyl groups
are the same, which proceeds in good yield under mild
conditions. This Mn(II)-catalyzed reaction of diorganyllmagnesium
lithium chloride complexes with o-halobenzoyl chlorides involves
acylation followed by cross-coupling reaction of the resulting
Grignard reagent and is thus more atom-economic and less time
consumingthantheequivalenttwostepprocedureusingGrignard
reagents. Current work in our laboratory is concerned with the
use of hetero-diorganylmagnesium compounds to put different
substituents on the arene and the ketone in one pot.
THF,-30°C,
1a
3a
Cl
O
Cl OH
n-Bu
Cl
n-Bu
+
+
+
n-Bu
n-Bu
n-Bu
5
6
7
8
Conversion (%)b
Entry
1
n-BunMX
3a
5
6
7
8
n-BuMgBr (2.6 equiv.)
51
10
23
9
4
2a
Experimental Section
2
3
4
5
n-Bu3MgLi (0.87 equiv.)
59
0
32
99
7
9
0
2
1
0
0
5
0
0
0
2
0
2b
General
n-BuCu(CN)MgBr (2.6 equiv.)
Melting points were recorded on an electrothermal digital melting
point apparatus and uncorrected. H NMR and 13C NMR spectra
2c
1
n-Bu2Mg (1.3 equiv.)
83
94
were obtained with a Bruker Avance 600 spectrometer in CDCl3
with TMS as an internal standard. Infrared spectra were recorded
withaBrukerTensor27 FT-IRspectrophotometerusingKBrpellets.
GC-MS was performed on a Finnigan Trace DSQ chromatograph.
The analytical data for the known compounds was found to match
the literature data.
2d
n-Bu2Mg•LiCl (1.3 equiv.)
2e
1
a Reactions were carried out with n-BunMX (2.6 equiv. of n-Bu) and
MnCl2 (0.1 equiv.) in THF at −30 ◦C for 0.5 h by pump.
b Conversions were determined by GC.
Materials
reagent for the tandem cross-coupling reaction with heavier
halogen-substituted benzoyl chlorides giving progressively lower
yields – only a modest yield was obtained using iodo-substituted
1c in the reaction, which is unusual in normal cross-coupling
reactions.
With these pleasing results in hand, the tandem cross-coupling
reaction of 1a with various dialkylmagnesium-lithium chloride
complexes 2 was investigated in the presence of 10 mol% MnCl2
in THF at −30 ◦C. (Table 3) The reactions of all dialkylmagnesium
All reactions were carried out under a argon atmosphere in
dried Schlenk-flask. THF and 1,4-dioxane were continously re-
fluxed and freshly distilled from sodium benzophenone ketyl
under nitrogen. LiCl (anhydrous, 99%), n-Bu2Mg (1.0 M in THF),
i-PrMgCl (1.0 M in THF), n-BuLi (2.5 M in hexane), 2-chlorobenzoyl
chloride, 3-chlorobenzoyl chloride, 4-chlorobenzoyl chlo-
ride, 2-bromobenzoyl chloride, 3-bromobenzoyl chloride,
4-bromobenzoyl chloride, 2-iodobenzoyl chloride, 1-bromo-4-
methylbenzeneand1-bromo-4-methoxybenzenewerepurchased
c
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Copyright ꢀ 2009 John Wiley & Sons, Ltd.
Appl. Organometal. Chem. 2010, 24, 57–63

An efficient MnCl2-catalyzed tandem acylation-cross-coupling reaction
Table 2. Tandem cross-coupling reaction of o-halobenzoyl chloride with dibutylmagnesiuma
O
O
10 mol% catalyst
+ n-Bu2Mg•LiCl
X1
n-Bu
X2
Substrate
THF, -30°C, 0.5h
n-Bu
2e
Entry
1
Catalyst
Product
Yield (%)b
93
MnCl2
Cl
O
n-Bu O
Cl
Cl
n-Bu
1a
1a
1a
3a
3a
2
3
4
FeCl3
80
83
76
Fe(acac)3
MnCl2
3a
3a
Br
I
O
1b
5
6
MnCl2
MnCl2
3a
41
84
O
Cl
O
1c
n-Bu O
Br
n-Bu
n-Bu
Cl
1d
3b
7
MnCl2
0
O
O
Cl
n-Bu
X
X=m-Cl, p-Cl, m-Br, p-Br
1e
a Reactions were carried out with n-Bu2Mg·LiCl(1.3 equiv.) and catalyst (0.1 equiv.) in THF at −30 ◦C for 0.5 h by pump.
b Yield after column.
from Alfa Aesar. MnCl2·4H2O (purum p.a.) and LiCl (anhy-
drous, 99%) were dried in a vacuum oven at 200 ◦C under
reduced pressure (0.1 torr) for 24 h. Organometallic reagents
[n-BuCu(CN)MgBr,[36] n-Bu3MgLi[30]] in Table 1 were prepared ac-
cording to the literature.
Typical Procedure for Tandem Reaction of o-Halogenbenzoyl
Chloride with Dialkylmagnesium
Magnesium turnings (44 mmol) were placed in an Ar-flushed flask
and THF (10 ml) was added. A solution of n-BuBr (40 mmol) in THF
(15 ml) was slowly added at room temperature (r.t.). The reaction
started within a few minutes. After addition, the reaction mixture
was stirred for 12 h at r.t. The gray solution of n-BuMgBr was
cannulated to another flask under argon and removed in this way
from the excess of magnesium. A yield of ca 95–98% of n-BuMgBr
(25 ml, 1.6 M in THF, 40 mmol) was obtained.
Procedure to Prepare some Organometallic Reagents
in Table 1
Entry l
A 10 ml Schlenk-flask, equipped with a magnetic stirring bar,
was charged with the MnCl2 (0.05 mmol), THF (2 ml) and
o-chlorobenzoyl chloride (0.5 mmol) were added and the solution
cooled to −30 ◦C. Subsequently, organometallic reagent [n-
BuMgBr (1.3 ml, 1.0 M in THF, 1.3 mmol)/n-BuCu(CN)MgBr (1.3 ml,
1.0 M in THF, 1.3 mmol)/(1.8 ml, 0.25 M in THF, 0.45 mmol)/n-
Bu2 Mg (0.65 ml, 1.0 M in THF, 0.65 mmol)/n-Bu2 Mg·LiCl (1.30 ml,
0.50 M in THF, 0.65 mmol)] was added by pump in 10 min and then
reactionmixturewasstirredatthistemperatureforanother20 min.
The mixture was quenched with HCl (5 ml, 1 M) and extracted with
Et2O (3 × 10 ml). The organic fractions were washed with brine,
dried over MgSO4, filtered and the solvent evaporated in vacuo.
Yields were determined by GC-MS.
Anhydrous LiCl (20 mmol) was placed in an Ar-flushed Schlenk-
flask and THF (10 ml) was added. A solution of n-BuMgBr (25 ml,
1.6 M in THF, 40 mmol) was added. After 5 min dry 1,4-dioxane
(4 ml, ∼10 vol%, ∼1.1 equiv. referring to MgCl2) was added.
The reaction was slightly exothermic and a white precipitate
was formed. After 2 h of stirring at room temperature, the white
precipitate was filtrated off under Ar. The concentration of the
resulting clear solution n-Bu2Mg·LiCl was about 0.5 M.
A 10 ml Schlenk-flask, equipped with a magnetic stirring
bar, was charged with the MnCl2 (0.05 mmol), THF (2 ml) and
o-chlorobenzoyl chloride (0.5 mmol) were added and the solution
cooled to −30 ◦C. Subsequently, n-Bu2Mg·LiCl (1.3 ml, 0.5 M,
0.65 mmol) was added by pump in 10 min and then the reaction
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F. Zhang et al.
A solution of i-PrBr (100 mmol) in THF (50 ml) was slowly added
at r.t. The reaction started within a few minutes. After addition,
the reaction mixture was stirred for 12 h at r.t. The gray solution
of i-PrMgBr·LiCl was cannulated to another flask under Ar and
removed in this way from the excess of magnesium. A yield of ca
95–98% of i-PrMgBr·LiCl (1.05 M in THF) was obtained.
Table 3. Tandemcross-couplingreactionofo-chlorobenzoylchloride
with dialkylmagnesiuma
O
Cl
O
R
Cl
10 mol% MnCl2
R
+
R2Mg•LiCl
THF, -30°C, 0.5h
A
dry and argon-flushed 50 ml Schlenk-flask, equipped
1a
2
3
with a magnetic stirrer and a septum, was charged with
i-PrMgBr·LiCl (25 ml, 1.0 M in THF, 25 mmol) and neat 1-bromo-4-
methoxybenzene (25 mmol). Dioxane (2.5 ml) was added in one
portion to the reaction mixture at 25 ◦C. The reaction mixture was
stirred at 25 ◦C and the completion of the Br/Mg exchange was
checked by GC-analysis using tetradecane as internal standard.
The Br/Mg-exchange was completed after 24 h at r.t.
A 10 ml Schlenk-flask, equipped with a magnetic stirring
bar, was charged with the MnCl2 (0.05 mmol), THF (2 ml) and
o-bromobenzoyl chloride (0.5 mmol) were added and the solution
cooled to −30 ◦C. Subsequently, (4-methoxyphenyl)2Mg·LiCl
(3.1 ml, 0.4 M, 1.2 mmol) was added and then reaction mixture
was stirred at this temperature for 1 h. The mixture was quenched
with HCl (5 ml, 1 M) and was extracted with Et2O (3 × 10 ml).
The organic fractions were washed with brine, dried over MgSO4,
filtered and the solvent evaporated in vacuo. The residue was
purified by chromatography on silica gel to give pure products.
Entry
Alkyl2Mg
Product
Yield (%)b
70
Et2Mg · LiCl
1
2
3
4
5
6
7
3c
O
Et
2f
Et
n-Pr2Mg · LiCl
3d
3e
3f
76
81
91
79
90
85
O
n-Pr
2g
n-Pr
i-Pr2Mg · LiCl
O
i-Pr
i-Pr
2h
n-Pent2Mg · LiCl
O
1-(2-butylphenyl)pentan-1-one (3a)[26]
n-Pent
n-Pent
2i
A colorless liquid. The spectra data is identical to the literature.
1-(1-butyl-2-naphthyl)pentan-1-one(3b)
Cyclopent2Mg · LiCl
3g
3h
3i
O
Cyclopent
Cyclopent
2j
n-Bu O
n-Bu
n-Hept2Mg · LiCl
O
A viscous slightly yellow liquid. IR:(KBr) vmax 2956, 2928, 2867,
1691, 1461, 1377, 812, 751 cm−1; 1H NMR: (600 MHz, CDCl3) δ 8.14
(d, J = 8.4 Hz, 1H, CH arom), 7.85 (d, J = 7.8 Hz, 1H, CH arom),
7.73 (d, J = 8.4 Hz, 1H, CH arom), 7.58–7.48 (m, 3H, CH arom), 3.11
(t, J = 7.8 Hz, 2H, CH2 to C O), 2.92 (t, J = 7.2 Hz, 2H, PhCH2),
1.75–1.68 (m, 4H, 2CH2), 1.55–1.50 (m, 4H, 2CH2), 1.00–0.94 (m,
6H, 2CH3); 13C NMR: (150 MHz, CDCl3) δ 207.30 (C O), 138.08 (C
arom), 137.26 (C arom), 134.38 (C arom), 132.26 (C arom), 128.73 (C
arom), 126.75 (C arom), 126.63 (C arom), 126.40 (C arom), 125.26 (C
arom), 123.69 (C arom), 43.19 (CH2 to C O), 34.11 (PhCH2), 29.35
(CH2), 26.60 (CH2), 23.40 (CH2), 22.56 (CH2), 14.03 (CH3), 14.01
(CH3); HRMS calcd for C19H24O 268.1827; found: 268.1830.
n-Hept
n-Hept
2k
n-Oct2Mg · LiCl
O
n-Oct
n-Oct
2l
a Reactions were carried out with dialkylmagnesium (1.3 equiv.) and
MnCl2 (0.1 equiv.) in THF at −30 ◦C for 0.5 h by pump.
b Yield after column.
1-(2-ethylphenyl)propan-1-one (3c)[37]
A colorless liquid. The spectra data is identical to the literature.
mixture was stirred at this temperature for another 20 min. The
mixture was quenched with HCl (5 ml, 1 M) and was extracted with
Et2O (3 × 10 ml). The organic fractions were washed with brine,
dried over MgSO4, filtered and the solvent was evaporated in
vacuo. The residue was purified by chromatography on silica gel
to give pure products.
1-(2-propylphenyl)butan-1-one (3d)[38]
A colorless liquid. The spectra data is identical to the literature.
1-(2-isopropylphenyl)-2-methylpropan-1-one(3e)[39]
A colorless liquid. The spectra data is identical to the literature.
Typical Procedure for the Reaction of o-Halogenbenzoyl
Chloride with Diarylmagnesium
1-(2-pentylphenyl)hexan-1-one (3f)[40]
Magnesium turnings (110 mmol) and anhydrous LiCl (100 mmol)
were placed in an Ar-flushed flask and THF (50 ml) was added.
A colorless liquid. The spectra data is identical to the literature.
c
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An efficient MnCl2-catalyzed tandem acylation-cross-coupling reaction
Table 4. Tandem cross-coupling reaction of o-chlorobenzoyl chloride with diarylmagnesiuma
R
R
O
Cl
O
10 mol% MnCl2
X
+
THF,-30°C,1h
2
R
Mg•LiCl
1
2
3
Entry
1
Aryl2Mg
Product
Yield (%)b
53
Ph
O
Cl
O
Ph
Cl
2
3j
Mg•LiCl
1a
2m
2
3
4
2m
3j
90
92
96
Br
O
O
Cl
Cl
1b
2m
3j
I
1c
1b
Me
Me
O
2
Mg•LiCl
2n
Me
3k
5
1b
88
OMe
OMe
O
2
Mg•LiCl
2o
OMe
3l
6
1b
75
NMe2
NMe2
O
2
Mg•LiCl
2p
NMe2
3m
a Reactions were carried out with diarylmagnesium (2.0–3.0 equiv.) and MnCl2 (0.1 equiv.) in THF at −30 ◦C for 1.0 h.
b Yield after column.
c
Appl. Organometal. Chem. 2010, 24, 57–63
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F. Zhang et al.
Cyclopentyl(2-cyclopentylphenyl)methanone (3g)
Cyclopent
Cyclopent
4-Methyl-biphenyl-2-yl)-(4-methyl-phenyl)-methanone(3k)
Me
O
O
A colorless liquid. IR:(KBr) vmax 2953, 2867, 1807, 1765, 1687,
1464, 1371, 1119, 1071, 758 cm−1 1H NMR: (600 MHz, CDCl3) δ
Me
;
7.39–7.35 (m, 3H, CH arom), 7.21–7.19 (m, 1H, CH arom), 3.47 (tt,
A white solid. M.p. = 152–153 ◦C IR:(KBr) vmax 3030, 2963, 1659,
1600, 1512, 1474, 1379, 1253, 1150, 1044, 923, 823, 775 cm−1; 1H
NMR: (600 MHz, CDCl3) δ 7.60 (d, J = 7.8 Hz, 2H, CH arom), 7.53
(t, J = 7.8 Hz, 2H, CH arom), 7.47–7.40 (m, 3H, CH arom), 7.16 (d,
J = 7.8 Hz, 1H, CH arom), 7.10 (d, J = 7.8 Hz, 2H, CH arom), 7.02
J = 15.6 Hz, 7.8 Hz, 1H, CH to C O), 3.20 (tt, J = 17.4 Hz, 8.4 Hz,
1H, PhCH), 1.86–1.62 (m, 8H, 4CH2), 1.58–1.25 (m, 8H, 4CH2); 13
C
NMR: (150 MHz, CDCl3) δ 208.83 (C O), 144.11 (C arom), 140.02 (C
arom), 129.34 (C arom), 126.05 (C arom), 125.53 (C arom), 124.30 (C
arom), 50.12 (CH to C O), 40.91 (PhCH), 34.71 (CH2), 28.81 (CH2),
(d, J = 7.8 Hz, 2H, CH arom), 2.34 (s, 3H, CH3), 2.25 (s, 3H, CH3); 13
C
26.52 (CH2), 25.20 (CH2), 25.08 (CH2); HRMS calcd for C17H22
O
NMR: (150 MHz, CDCl3) δ 198.51 (C O), 143.82 (C arom), 141.02 (C
arom), 139.12 (C arom), 137.37 (C arom), 137.03 (C arom), 134.88 (C
arom), 130.27 (C arom), 130.17 (C arom), 130.12 (C arom), 129.07 (C
arom), 128.94 (C arom), 128.81 (C arom), 128.56 (C arom), 126.69 (C
arom), 22.25 (CH3), 21.72 (CH3); HRMS calcd for C21H18O 286.1358;
found: 286.1366.
242.1671; found: 242.1678.
1-(2-Heptylphenyl)octan-1-one (3h)
O
n-Hept
n-Hept
4-Methoxy-biphenyl-2-yl)-(4-methoxy-phenyl)-methanone(3l)
OMe
A colorless liquid. IR:(KBr) vmax 2924, 2858, 1689, 1457, 1372, 1220,
653 cm−1; 1H NMR: (600 MHz, CDCl3) δ 7.52 (d, J = 7.8 Hz, 1H, CH
arom), 7.37–7.35 (m, 1H, CH arom), 7.26–7.22 (m, 2H, CH arom),
2.86 (t, J = 7.8 Hz, 2H, CH2 to C O), 2.76 (t, J = 7.8 Hz, 2H, PhCH2),
1.72–1.67 (m, 2H, CH2), 1.61–1.53 (m, 2H, CH2), 1.35–1.26 (m,
16H, 8CH2), 0.89–0.86 (m, 6H, 2CH3); 13C NMR: (150 MHz, CDCl3) δ
205.73 (C O), 142.29 (C arom), 139.10 (C arom), 130.94 (C arom),
130.73 (C arom), 127.90 (C arom), 125.58 (C arom), 42.38 (CH2
to C O), 33.84 (PhCH2), 32.07 (CH2), 31.93 (CH2), 31.81 (CH2),
29.78 (CH2), 29.40 (CH2), 29.28 (CH2), 29.23 (CH2), 24.51 (CH2),
22.75 (CH2), 22. 71 (CH2), 14.18 (CH3), 14.15 (CH3); HRMS calcd for
C21H34O 302.2610; found: 302.2606.
O
OMe
A white solid. M.p. = 101–102 ◦C IR:(KBr) vmax 2933, 2839, 1644,
1601, 1511, 1450, 1301, 1251, 1144, 1023, 926, 841, 765 cm−1; 1H
NMR: (600 MHz, CDCl3) δ 7.60 (d, J = 8.4 Hz, 2H, CH arom), 7.53
(t, J = 7.2 Hz, 2H, CH arom), 7.46–7.39 (m, 3H, CH arom), 7.24 (d,
J = 8.4 Hz, 1H, CH arom), 6.76 (t, J = 8.4 Hz, 4H, CH arom), 3.80 (s,
3H, OCH3), 3.73 (s, 3H, OCH3); 13C NMR: (150 MHz, CDCl3) δ 197.66
(C O), 163.38 (C arom), 158.92 (C arom), 140.33 (C arom), 139.18
(C arom), 132.76 (C arom), 132.39 (C arom), 130.34 (C arom), 130.05
(C arom), 129.99 (C arom), 129.95 (C arom), 128.42 (C arom), 126.62
(C arom), 113.79 (C arom), 113.45 (C arom), 55.44 (OCH3), 55.20
(OCH3); HRMS calcd for C21H18O3 318.1256; found: 318.1259.
1-(2-Octylphenyl)nonan-1-one (3i)
O
n-Oct
n-Oct
4-Dimethylamino-biphenyl-2-yl)-(4-dimethylamino-phenyl)-
methanone (3m)
A colorless liquid. IR:(KBr) vmax 2953, 2929, 2857, 1690, 1467, 1366,
752 cm−1; 1H NMR: (600 MHz, CDCl3) δ 7.52 (d, J = 7.8 Hz, 1H, CH
arom), 7.37–7.35 (m, 1H, CH arom), 7.26–7.22 (m, 2H, CH arom),
2.86 (t, J = 7.2 Hz, 2H, CH2 to C O), 2.76 (t, J = 7.8 Hz, 2H,
PhCH2), 1.71–1.68 (m, 2H,CH2), 1.56–1.54 (m, 2H,CH2), 1.34–1.22
(m, 20H, 10CH2), 0.88 (m, 6H, 2CH3); 13C NMR: (150 MHz, CDCl3)
δ 205.59 (C O), 142.28 (C arom), 139.11 (C arom), 130.92 (C
arom), 130.69 (C arom), 127.88 (C arom), 125.55 (C arom), 42.35
(CH2 to C O), 33.83 (PhCH2), 32.04 (CH2), 31.97 (CH2), 31.92
(CH2), 29.82 (CH2), 29.56 (CH2), 29.52 (CH2), 29.43 (CH2), 29.35
(CH2), 29.25 (CH2), 24.50 (CH2), 22.74 (CH2), 22.72 (CH2), 14.18
(CH3), 14.14 (CH3); HRMS calcd for C23H38O 330.2923; found:
330.2917.
NMe2
O
NMe2
A green solid. M.p. = 171–173 ◦C IR:(KBr) vmax 3898, 1593, 1531,
1478, 1441, 1370, 1291, 1190, 1142, 1062, 934, 817, 762 cm−1
;
1H NMR: (600 MHz, CDCl3) δ 7.68 (d, J = 9.0 Hz, 2H, CH arom),
7.50–7.46 (m, 3H), 7.39–7.33 (m, 2H, CH arom), 7.25 (d, J = 8.4 Hz,
1H, CH arom), 6.62 (d, J = 9.0 Hz, 2H, CH arom), 6.54 (d, J = 9.0 Hz,
2H, CH arom), 3.02 [s, 6H, N(CH3)2], 2.90 [s, 6H, N(CH3)2]; 13C NMR:
(150 MHz, CDCl3)δ 197.32(C O), 153.28(Carom), 149.61(Carom),
140.53 (C arom), 139.68 (C arom), 132.52 (C arom), 129.75 (C arom),
Biphenyl-2-yl-phenyl-methanone (3j)[41]
A white solid. The spectra data is identical to the literature.
c
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Copyright ꢀ 2009 John Wiley & Sons, Ltd.
Appl. Organometal. Chem. 2010, 24, 57–63

An efficient MnCl2-catalyzed tandem acylation-cross-coupling reaction
129.60 (C arom), 129.28 (C arom), 128.60 (C arom), 128.19 (C arom),
125.75 (C arom), 125.34 (C arom), 112.35 (C arom), 110.42 (C arom),
40.47 (2CH3), 40.01 (2CH3); HRMS calcd for C23H24N2O 344.1889;
found: 344.1895.
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Acknowledgment
We are grateful for support from the National Natural Science
Foundation of China (20702043), Jiangsu Provincial Natural
Science Foundation (BK2006549) P. R. China, and Program for
New Century Excellent Talents in Yangzhou University. We also
acknowledge the good advice from Dr Daniel Whelligan.
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