Tetrahedron p. 2307 - 2322 (1989)
Update date:2022-07-29
Topics:
McIntyre, C. Rupert
Scott, Fiona E.
Simpson, Thomas J.
Trimble, Laird A.
Vederas, John C.
Incorporation of (13)C-labelled acetates and methionine, (14)C and (2)H-labelled ethyl 3,5-dimethylorsellinate into terretonin (5) by cultures of Aspergillus terreus indicated that its biosynthesis proceeds via a mixed polyketide-terpenoid (meroterpenoid) pathway.Incorporation of (18)O2 gas and ethyl 3,5-dimethylorsellinate (7) doubly labelled with (13)C and (18)O in the carbonyl of the carboxyl group and at the C-6 position into terretonin (5) and observation of (18)O isotope-induced shifts in the (13)C n.m.r. spectra and GC/MS studies of the enriched metabolites determined the origin of all of the oxygen atoms in (5) and provided mechanistic insight into the biosynthetic pathway.
View MoreContact:+86-571-87859231, 87859237, 87859239
Address:1606,Huarong Times Mansion, No.3880 Jiangnan Avenue, Binjiang District, Hangzhou, China, 310053
Wuhan Fortuna Chemical Co.,Ltd
website:http://www.fortunachem.com
Contact:86-27-59207850
Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China
Taizhou YOJOY Chemical Co., Ltd.
Contact:13857143241
Address:Yangfu Industrial Park, Xianju, Zhejiang, P. R. China
SPRING CHEMICAL INDUSTRY CO.,LTD
Contact:86-187-66672125
Address:linchi industry park.zouping
Henan zhongda Biological Engineering Co., Ltd
Contact:86-28-18109029985
Address:shenzhou road,xuedian industrial estate,zhengzhou city,henan province CHN
Doi:10.1016/j.tetlet.2009.10.001
(2009)Doi:10.1021/op1000447
(2010)Doi:10.1016/j.bmcl.2013.03.098
(2013)Doi:10.1021/ic100313j
(2010)Doi:10.1021/jm00129a028
(1989)Doi:10.1016/S0040-4039(00)99128-7
(1989)
