Bioorganic and Medicinal Chemistry p. 1273 - 1279 (2010)
Update date:2022-08-05
Topics: Inhibitors
Chimenti, Franco
Fioravanti, Rossella
Bolasco, Adriana
Chimenti, Paola
Secci, Daniela
Rossi, Francesca
Yá?ez, Matilde
Orallo, Francisco
Ortuso, Francesco
Alcaro, Stefano
Cirilli, Roberto
Ferretti, Rosella
Sanna, M. Luisa
A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.
View MoreShangHai Ruiyi Medical Technology Co.,Ltd.
Contact:+86-21-54718086
Address:No951 Jianchuan RD,Minhang District
Contact:0519-85170101-802
Address:Fifth Floor,B of Beihua Buliding,520 Road of Science and Education City,Changwu middle road NO.801,Wujin District,Changzhou,Jiangsu province
Hefei TNJ chemical industry co.,ltd
website:https://www.tnjchem.com
Contact:+86-551-65418695
Address:B911 Xincheng Business Center, Qianshan Road, Hefei Anhui China
Weifang Adde Economic And Trade Co.,LTD.
Contact:86-536-8885548
Address:Room 1402,Wanda Plaza B Block,No.958,Yuanfei Road,Kuiwen District
Contact:86-571-86737118-8689
Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Doi:10.1016/j.tet.2009.12.049
(2010)Doi:10.1016/j.ejmech.2009.11.046
(2010)Doi:10.1002/chem.200902544
(2010)Doi:10.1021/ol100012y
(2010)Doi:10.1016/j.tet.2010.01.025
(2010)Doi:10.1021/ja100833h
(2010)