Organic and Biomolecular Chemistry p. 1399 - 1405 (2010)
Update date:2022-08-05
Topics:
Zhang, Guang-Wu
Zheng, Dong-Hua
Nie, Jing
Wang, Teng
Ma, Jun-An
A general method for the one-pot, three-component Strecker reaction of ketones was developed using Bronsted acids as organocatalysts. A series of α-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.
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(2010)
