An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: Discovery of macrocyclic histone deacetylase inhibitors

DOI: 10.1021/ja105119r

Source and publish data:

Journal of the American Chemical Society p. 16962 - 16976 (2010)

Update date:2022-08-02

Topics:

Authors:

Marcaurelle, Lisa A.

Comer, Eamon

Dandapani, Sivaraman

Duvall, Jeremy R.

Gerard, Baudouin

Kesavan, Sarathy

Lee, Maurice D.

Liu, Haibo

Lowe, Jason T.

Marie, Jean-Charles

Mulrooney, Carol A.

Pandya, Bhaumik A.

Rowley, Ann

Ryba, Troy D.

Suh, Byung-Chul

Wei, Jingqiang

Young, Damian W.

Akella, Lakshmi B.

Ross, Nathan T.

Zhang, Yan-Ling

Fass, Daniel M.

Reis, Surya A.

Zhao, Wen-Ning

Haggarty, Stephen J.

Palmer, Michelle

Foley, Michael A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/ja105119r

An aldol-based build/couple/pair (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules. In the build phase, a series of asymmetric syn- and anti-aldol reactions were performed to produce four ster

Full text of DOI:10.1021/ja105119r

Products guided by the article

Product name:C₃₇H₄₅F₃N₄O₆

Cas No:1222377-88-9

R&D Labs maybe for 1222377-88-9

Shanghai Sinofluoro Scientific Co., Ltd

Contact:+86-21-64279360

Address:Room 1006,Building 3,#58 East Xinjian Road, Shanghai ,201100,China,
Changzhou Sunlight Pharmaceutical Co., Ltd.

Contact:+86-519-83131668;83139028;83138042;83137041

Address:JiuliStreet, Benniu Town Changzhou City, Jiangsu Province
Anhui Gusheng Import&Export CO.,LTD

Contact:86-551-63662296

Address:Jinzhai Road NO.162 ,hefei, china
SuZhou Bichal Biological Technology CO.,LTD

Contact:+86-512-68051130

Address:NO.32 huoju road HI-TECH Industrial development zone SuZhou China
TAIZHOU XINGCHENG CHEMPHARM CO.,LTD.

Contact:0086-0576-88551200,88886292 ,88880039

Address:B Area. 10 Floor.Yaodadasha. 289#.Shifu Road.Taizhou.Zhejiang.China

Relevant to this article

Synthesis, characterization, and crystal structure of a new supramolecular Cd^II complex with halogen-substituted salen-type bisoxime

Doi:10.1080/15533174.2012.753614
(2013)
Cleavage of the C-S bond with the formation of a binuclear copper complex with 2-thiolato-3-phenyl-5-(pyridine-2-ylmethylene)-3,5-dihydro-4H-imidazole-4- one. A new mimic of the active site of N₂O reductase

Doi:10.1039/c3dt50422k
(2013)
Control of glycoprotein synthesis. Characterization of (1->4)-N-acetyl-β-D-glucosaminyltransferases acting on the α-D-(1->3)- and α-D-(1->6)-linked arms of N-linked oligosaccharides

Doi:10.1016/0008-6215(92)85022-R
(1992)
The reaction of ortho-halogenated aromatic aldazine ligands with Fe₂(CO)₉: Symmetrical cleavage of the azine and carbon-halogen activation

Doi:10.1016/j.jorganchem.2004.04.049
(2004)
Biological evaluation of new mimetics of annonaceous acetogenins: Alteration of right scaffold by click linkage with aromatic functionalities

Doi:10.1016/j.ejmech.2014.03.062
(2014)
Doi:10.1021/ja00443a074
(1977)

Article Doi