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ARTICLE
Journal Name
Statistics
DOI: 10.1039/C6OB01850E
Three independent experiments were conducted and each
experiment was comprised of at least two internal replicates.
Data are presented as mean ± SD or mean ± SEM. Statistical
analysis was performed by using an unpaired Student’s t-test.
Statistically significant data were detailed when P<0.05).
10, 1609-1612.
11. V. Pavlov, P. Kong Thoo Lin and V. Rodilla, Chem-Biol Inter,
2001, 137, 15-24.
12. J. Oliveira, L. Ralton, J. Tavares, A. Codeiro-Da-Silva, C.S.
Bestwick, A. MacPherson and P. Kong Thoo Lin, Bioorg. Med.
Chem., 2007, 15, 541-545.
Acknowledgements
13. G.A. Barron, G. Bermano, A. Gordon and P. Kong Thoo Lin, Eur.
J. Med. Chem., 2010, 45, 1430-1437.
The authors acknowledge the Robert Gordon University for financial
support, and the EPSRC National Mass Spectrometry Service Centre
at Swansea University, Swansea for mass spectral analysis.
14. R. Lima, G.A. Barron, J. Grabowska, G. Bermano, S. Kaur, N. Roy,
M. Vasconcelos and P. Kong Thoo Lin, Anti-Cancer Agents Med.
Chem., 2013, 3, 414-421.
References
1. R. Siegel, D. Naishadham and A. Jemal, CA-Cancer J Clin, 2013,
63, 11-30.
15. A. Birch, P. Kenny, I. Simpson and P. Whittamore, Bioorg. Med.
Chem. Lett., 2009, 19, 850–853.
2. A. Redmond, C. Byrne, F. Bane, G. Brown, P. Tibbitts, K. O’Brien,
A. Hill, J. Carroll and L.Young, Oncogene, 2015, 34, 3871-3880.
16. P. Gleeson, G. Bravi, S. Modi and D. Lowe, Bioorg. Med. Chem.,
2009, 17, 5906–5919.
3. A. Becorpi, G. Sisti, F. Sorbi, E. Malosso and S. Guaschino, Clin
Cases Miner Bone Metab, 2014, 11, 110-113.
17. P. Hajduk and D. Sauer, J. Med. Chem., 2008, 51, 553–564.
18. S. Scultes, C. de Graaf, H. Berger, M. Mayer, A. Steffen, E.
Haaksma, I. de Esch, R. Leurs and O. Kramer, Med. Chem.
Commun., 2012, 3, 584-591.
4. B. Lehmann and J. Pietenpol, J Pathol, 2013, 232, 142-150.
5. S.F. Chen, D.L. Behrens, C.H. Behrens, P.M. Czerniak, D.L.
Dexter, B.L. Dusak, J.R. Fredericks, K.C. Gale, J.L. Gross, J.B.
Jiang, M. Kirshenbau, R.J. McRipley, L.M. Papp, A.D Patten,
F.W. Perrella, S.P. Seitz, M.P. Stafford, J.H. Sun, T. Sun, M.A.
Wuonola and D.D Von Hoff, Anti-Cancer Drugs, 1993, 4, 4.
19. P. Scaria and R. J. Shafer, J. Biol. Chem., 1991, 266, 5417-5423.
20. W. Chen, J. Turro and D. Tomalia, Langmuir, 2000, 16, 15-19.
21. P. Liu, B. Wu, J. Liu, Y. Dai, Y. Wang and K. Wang, Inorg. Chem.,
2016, 55, 1412-1422.
6. M.F. Braña, M. Cacho, A. Gradillas, B. de Pascual-Teresa and A.
Ramos, Curr. Pharm. Des., 2001, 7, 1745-1780.
22. M.F. Braña, M. Cacho, A. Ramos, M. Dominguez, J. Pozuelo, C.
Abradelo, M. Rey-Stolle, M. Yuste, C. Carrasco and C. Bailly,
Org. Biomol. Chem., 2003, 1, 648-654
7. V. Pavlov, P. Kong Thoo Lin and V. Rodilla, Chem Biol Interact,
2001, 137, 15-24.
23. T. Zhi-Yong, L. Jing-Hua, L. Qian, Z. Feng-Lei, Z. Zhong-Hua and
8. M. Llombart, A. Poveda, E. Forner, C. Fernández Martos, C.
Gaspar, M. Muñoz, T. Olmos, A. Ruiz, V. Soriano, A. Benavides,
M. Martin, E. Schlick and V. Guillem, Invest New Drugs, 1992,
10, 177–181.
W. Chao-Jie, Molecules, 2014, 19, 7646-7668.
24. M.F. Braña, M. Cacho, M. Garcia, B. de Pascual-Teresa, A.
Ramos, M. Dominguez, J. Pozuelo, C. Abradelo, M. Rey-Stolle,
M. Yuste, M. Banez-Coronel and J. Lacal, J. Med. Chem., 2004,
47, 1391-1399.
9. M.F. Braña and A. Ramos, Curr. Med. Chem. Anti-Canc. Agents,
2001, 1, 237-255.
12 | J. Name., 2012, 00, 1-3
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