Reduction of Aldehyde with Tributyltin Hydride-HMPA Combined System

Article abstract of DOI:10.1246/cl.1989.619

Bu3-SnH-HMPA combined system is an efficient reagent for the reduction of aldehydes.The reaction proceeds in good yields, and chemoselective carbonyl reduction is achieved for the substrate which includes another reducible group.Moreover, the intermediate, tin alkoxide, undergoes further reaction such as the preparation of ethers and heterocyclic compounds in the one pot procedure.