Medicinal Chemistry Research p. 443 - 452 (2011)
Update date:2022-08-02
Topics:
Aytemir, Mutlu Dilsiz
Oezcelik, Berrin
A novel series of 6-chloromethyl-3-hydroxy-2- substituted 4H-pyran-4-one derivatives were synthesized and tested for their antibacterial, antifungal and antiviral in vitro properties. In the view of activity results, compounds 8-11 (MIC: 8 μg/ml) were more remarkably active against Staphylococcus aureus and Enterococcus faecalis. Compounds 1-7 were highly active against Candida albicans and C. parapsilosis with MIC value of 8 μg/ml. Compound 9 bearing 3-chlorophenyl moiety was determined to be the most active compound against RNA virus PI-3.
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