Tetrahedron Letters p. 6779 - 6782 (1988)
Update date:2022-08-04
Topics:
Bugg, Timothy D. H.
Abell, Chris
Coggins, John R.
Analogues of 3-dehydroshikimic acid which lack the C-4 and C-5 hydroxyl groups have been synthesised and assayed as substrates for shikimate dehydrogenase.The presence of the C-4 hydroxyl group is found to be very important for specificity, whereas the C-5 hydroxyl group is not.The enzyme exhibits enantioselectivity at C-1 and C-4 of the racemic substrate analogues.
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