Dihydropyrimidines: Novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity

DOI: 10.1021/jm00130a029

Source and publish data:

Journal of Medicinal Chemistry p. 2399 - 2406 (1989)

Update date:2022-08-03

Topics: Potent Dihydropyrimidines antihypertensive Calcium antagonists

Authors:

Cho Cho

Ueda Ueda

Shima Shima

Mizuno Mizuno

Hayashimatsu

Ohnaka Ohnaka

Takeuchi

Hamaguchi

Aisaka Aisaka

Hidaka Hidaka

Kawai Kawai

Takeda Takeda

Ishihara

Funahashi

Satoh Satoh

Morita Morita

Noguchi Noguchi

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Article abstract of DOI:10.1021/jm00130a029

The novel calcium antagonists 3-N-substituted-3,4-dihydropyrimidines 1 and 9 and 3-N-substituted-dihydropyrimidin-2(1H)-ones 8 were regioselectively synthesized in good yields. Compounds 1 [especially 1s [R¹ = (CH₂)₂N(benz

Full text of DOI:10.1021/jm00130a029

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