Synthesis and biochemical studies of 7-substituted 4,6-androstadiene-3,17-diones as aromatase inhibitors

DOI: 10.1021/jm00163a017

Source and publish data:

Journal of Medicinal Chemistry p. 101 - 105 (1990)

Update date:2022-08-04

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Authors:

Brueggemeier

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Article abstract of DOI:10.1021/jm00163a017

Inhibitors of aromatase, the cytochrome P-450 enzyme complex responsible for the biosynthesis of estrogens, may be useful as therapeutic agents for the treatment of estrogen-dependent disease states such as breast and endometrial cancer. Several 7α-thio-s

Full text of DOI:10.1021/jm00163a017

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Product name:7-phenyl-4,6-androstadiene-3,17-dione

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