A SIMPLE PREPARATION OF S-ALKYL HOMOCYSTEINE DERIVATIVES: S-PHOSPHONOMETHYL HOMOCYSTEINES AS INHIBITORS OF GLUTAMINE SYNTHETASE

Article abstract of DOI:10.1016/S0040-4039(00)82263-7

A facile synthesis of S-alkyl homocysteines is described which features the coupling of sodium alkyl thiolates with methyl 4-bromo-2-phthalimidobutyrate, followed by hydrolysis.This approach is exemplified by the synthesis of S-phosphonomethyl homocysteine sulfone, a new inhibitor of the enzyme glutamine synthetase.