Linear free-energy relationship analysis of a catalytic desymmetrization reaction of a diarylmethane-bis(phenol)

Article abstract of DOI:10.1021/ol100927m

(Figure presented) Linear free-energy relationships have been found for enantioselectivity and various steric parameters in an enantioselective desymmetrization of symmetrical bis(phenol) substrates. The potential origin of this observation and the role of different steric parameters are discussed.