Photochemical synthesis of nucleoside analogues from cyclobutanones: Bicyclic and isonucleosides

DOI: 10.3390/molecules15063816

Source and publish data:

Molecules p. 3816 - 3828 (2010)

Update date:2022-07-30

Topics:

Authors:

Jaffer, Mileina

Ebead, Abdelaziz

Lee-Ruff, Edward

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Article abstract of DOI:10.3390/molecules15063816

The preparation of two nucleoside analogues are reported. Both syntheses involve a key photochemical ring-expansion of cyclobutanones to an oxacarbene and its subsequent scavenging by 6-chloropurine. The synthesis of a bicyclic (locked) purine starts from

Full text of DOI:10.3390/molecules15063816

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