STEREOSELECTIVE SYNTHESIS OF THE HYDROXY AMINO ACID MOIETY OF AI-77-B, A GASTROPROTECTIVE SUBSTANCE

Article abstract of DOI:10.1016/S0040-4039(00)82339-4

The hydroxy amino acid moiety of Al-77-B (1) has been prepared as its protected form 2 from the (R)-glyceric acid derivative 3 in an efficiently stereoselective manner through the direct C-acylation using diphenyl phosphorazidate and the hydroxy-directed