Bioorganic and Medicinal Chemistry p. 3066 - 3077 (2010)
Update date:2022-08-06
Topics:
Karki, Radha
Thapa, Pritam
Kang, Mi Jeong
Jeong, Tae Cheon
Nam, Jung Min
Kim, Hye-Lin
Na, Younghwa
Cho, Won-Jea
Kwon, Youngjoo
Lee, Eung-Seok
A new series of 2,4-diphenyl-6-aryl pyridines containing hydroxyl group(s) at the ortho, meta, or para position of the phenyl ring were synthesized, and evaluated for topoisomerase I and II inhibitory activity and cytotoxicity against several human cancer cell lines for the development of novel anticancer agents. Structure-activity relationship study revealed that the substitution of hydroxyl group(s) increased topoisomerase I and II inhibitory activity in the order of meta > para > ortho position. Substitution of hydroxyl group on the para position showed better cytotoxicity.
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Doi:10.1016/j.bmc.2010.03.055
(2010)Doi:10.1021/jo100260k
(2010)Doi:10.1016/j.bmc.2010.03.013
(2010)Doi:10.1016/j.tet.2010.03.041
(2010)Doi:10.1007/s11172-009-0029-z
(2009)Doi:10.1021/ic100108h
(2010)
