Hf(OTf)4-Catalyzed regioselective N -aminomethylation of indoles and related NH-containing heterocycles

Article abstract of DOI:10.1021/jo1006043

Figure presented Under Lewis acidic conditions using Hf(OTf)₄, the aminomethylation of an indole derivative with a typical N,O-acetal preferentially produced kinetically favored N-aminomethylated indole derivatives instead of thermodynamically favored 3-aminomethylated indoles.