Bioorganic and Medicinal Chemistry Letters p. 1219 - 1224 (2010)
Update date:2022-08-05
Topics: Pharmacological evaluation Characterization Optimization Structure-Activity Relationship (SAR) Analysis Toxicity and Safety Assessment Publication and Reporting Design and Molecular Modeling
Beattie, David
Brearley, Andrew
Brown, Zarin
Charlton, Steven J.
Cox, Brian
Fairhurst, Robin A.
Fozard, John R.
Gedeck, Peter
Kirkham, Paul
Meja, Koremu
Nanson, Lana
Neef, James
Oakman, Helen
Spooner, Gillian
Taylor, Roger J.
Turner, Robert J.
West, Ryan
Woodward, Hannah
The synthesis of two series of 4′-aza-carbocyclic nucleosides are described in which the 4′-substituent is either a reversed amide, relative to the carboxamide of NECA, or an N-bonded heterocycle. Using established purine substitution patterns, potent and
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(2010)
