Synthesis of Pyranoindoles as Conformationally Restricted Analogues of the Serotonin Antagonist ICS 205-930 and as Precursors to 2-Vinylindoles

DOI: 10.1021/jo00281a018

Source and publish data:

Journal of Organic Chemistry p. 4785 - 4795 (1989)

Update date:2022-09-26

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Authors:

Macor, John E.

Ryan, Kevin

Newman, Michael E.

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Article abstract of DOI:10.1021/jo00281a018

A useful synthesis of some pyrano<4,3-b>indoles is described that allows access to conformationally restricted analogues of the serotonin (5HT₃) antagonist, ICS 205-930.These pyrano<4,3-b>indoles can be converted in one step to 2-vinylindole derivatives.

Full text of DOI:10.1021/jo00281a018

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