Bioorganic and Medicinal Chemistry Letters p. 1515 - 1518 (1997)
Update date:2022-09-26
Topics:
Kohno, Yasushi
Awano, Katsuya
Miyashita, Mitsutomo
Fujimori, Shizuyoshi
Kuriyama, Kazuhiko
Sakoe, Yasuhiko
Kudoh, Shinji
Saito, Koji
Kojima, Eisuke
A study of the modification of N-alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone destruction.
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Doi:10.1039/jr9490002198
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