SYNTHESIS AND DNA CROSSLINKING ABILITY OF A DIMERIC ANTHRAMYCIN ANALOG

DOI: 10.1016/S0040-4039(00)80691-7

Source and publish data:

Tetrahedron Letters p. 5105 - 5108 (1988)

Update date:2022-08-04

Topics:

Authors:

Farmer, J.Dean

Rudnicki, Suzanne M.

Suggs, J.William

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Article abstract of DOI:10.1016/S0040-4039(00)80691-7

Linked analogs of the DNA binding antibiotic anthramycin are made via nucleophilic aromatic substitution followed by reduction-cyclization.The linked compounds protect DNA from restriction endonucleases and reversibly crosslink DNA.

Full text of DOI:10.1016/S0040-4039(00)80691-7

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