Nucleophilic Opening of Chiral Bis(aziridines): A Route to Enantiomerically Pure α-Amino Aldehydes or Acids and Polysubstituted Piperidines

DOI: 10.1021/jo00283a028

Source and publish data:

Journal of Organic Chemistry p. 5324 - 5330 (1989)

Update date:2022-08-06

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Authors:

Dureault, Annie

Tranchepain, Isabelle

Depezay, Jean-Claude

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Article abstract of DOI:10.1021/jo00283a028

α-Amino aldehydes or acids can be obtained by nucleophilic opening of suitably protected chiral bis(aziridines) derived from D-mannitol.Nucleophiles consist of a wide range of organometallic and heteronucleophilic reagents.Reaction orientation toward bis-

Full text of DOI:10.1021/jo00283a028

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