Synthesis of erythronolide A via a very efficient macrolactonization under usual acylation conditions with the Yamaguchi reagent

Article abstract of DOI:10.1016/S0040-4039(00)97066-7

Macrolactonization of 3,5-O-(3,4-dimethoxybenzylidene)-9,11-O-(2,4,6-trimethylbenzylidene)- (9S)-9-dihydroerythronolide A seco-acid (4) was reexamined under various conditions and found to proceed rapidly only by treatment of 4 with Yamaguchi's reagent, 2