Bioorganic and Medicinal Chemistry Letters p. 3235 - 3239 (2010)
Update date:2022-08-05
Topics:
Wu, Frank
Büttner, Frank H.
Chen, Rhonda
Hickey, Eugene
Jakes, Scott
Kaplita, Paul
Kashem, Mohammed A.
Kerr, Steven
Kugler, Stanley
Paw, Zofia
Prokopowicz, Anthony
Shih, Cheng-Kon
Snow, Roger
Young, Erick
Cywin, Charles L.
Two closely related scaffolds were identified through an uHTS campaign as desirable starting points for the development of Rho-Kinase (ROCK) inhibitors. Here, we describe our hit-to-lead evaluation process which culminated in the rapid discovery of potent leads such as 22 which successfully demonstrated an early in vivo proof of concept for anti-hypertensive activity.
View MoreTIANJIN FESTO CHEMICAL CO.,LTD(expird)
Contact:86-22-25814570
Address:No.12th,5th Ave.,TEDA,Tianjin,China
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Contact:+86-21-5161 3915
Address:Shanghai YangPu
Contact:+8613400661290
Address:No 908,Kangwan Rd, Liuyang Economic
Guangzhou Swan Chemical Co., Ltd.
Contact:+86-20-31075659
Address:NO.301, Hong ba fang investment BLDG 1,Guan chong village,Shiqi town,Panyu district,Guangzhou
Jiangsu Taihu New Materials Holding Co., Ltd
Contact:+86-519-86160108
Address:Xueyan Town, Changzhou City, Jiangsu Province, 213169, China
Doi:10.1016/j.tet.2019.130711
(2019)Doi:10.1080/00397919108016762
(1991)Doi:10.1002/jhet.5570420508
(2005)Doi:10.1111/jphp.12982
(2018)Doi:10.1021/jo0101407
(2001)Doi:10.1039/b617595c
(2007)