REGIOSELECTIVE DEPROTECTION OF 3',5'-O-ACYLATED PYRIMIDINE NUCLEOSIDES BY LIPASE AND ESTERASE

DOI: 10.1016/S0040-4039(01)80666-3

Source and publish data:

Tetrahedron Letters p. 3819 - 3820 (1989)

Update date:2022-09-26

Topics:

Authors:

Uemura, Atsuhiko

Nozaki, Kenji

Yamashita, Jun-ichi

Yasumoto, Mitsugi

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Article abstract of DOI:10.1016/S0040-4039(01)80666-3

A lipase was found to catalyze the regioselective hydrolysis at the secondary hydroxyl group of 2'-deoxy 3',5'-di O-hexanoyl pyrimidine nuclosides, whereas a protease catalyzes that at the primary hydroxyl group.

Full text of DOI:10.1016/S0040-4039(01)80666-3

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Product name:Hexanoic acid (2R,3S,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

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