REGIOSELECTIVE DEPROTECTION OF 3',5'-O-ACYLATED PYRIMIDINE NUCLEOSIDES BY LIPASE AND ESTERASE

DOI: 10.1016/S0040-4039(01)80666-3

Source and publish data:

Tetrahedron Letters p. 3819 - 3820 (1989)

Update date:2022-09-26

Topics:

Authors:

Uemura, Atsuhiko

Nozaki, Kenji

Yamashita, Jun-ichi

Yasumoto, Mitsugi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(01)80666-3

A lipase was found to catalyze the regioselective hydrolysis at the secondary hydroxyl group of 2'-deoxy 3',5'-di O-hexanoyl pyrimidine nuclosides, whereas a protease catalyzes that at the primary hydroxyl group.

Full text of DOI:10.1016/S0040-4039(01)80666-3

Products guided by the article

Product name:Hexanoic acid (2R,3S,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Cas No:123739-80-0

R&D Labs maybe for 123739-80-0

X.T.Y Environ-Tech Co.,Ltd

Contact:+86-310-7092106

Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
Tianjin Anda North Industrial & Business Co.Ltd.

Contact:86-22-24999306

Address:No.11 Erwei Road,Dongli Development Area,Tianjin,China
Zhejiang Sucon Silicone Co.,Ltd

Contact:+86-575-88046692

Address:Qisheng Rd., Paojiang Industrial Zone, Shaoxing, Zhejiang, China.
Feis International Trade Co,. Ltd

Contact:13961823444-18235944442

Address:Wuxi jiangsu
Wuhan Jadechem International Trade Co.,Ltd.

website:http://www.jadechem-intl.com

Contact:+86-27-83527060

Address:Room 502,Building C11,Software new city No.8,Huacheng Avenue,East Lake High-tech development zone,Wuhan,Hubei,China

Relevant to this article

Synthesis of polynitroxides based on nucleophilic aromatic substitution

Doi:10.1021/ol101529u
(2010)
Azide - Alkyne "click" conjugation of 8-aza-7-deazaadenine-DNA: Synthesis, duplex stability, and fluorogenic dye labeling

Doi:10.1021/bc100090y
(2010)
Synthesis of para-substituted 1,4,5,6,7,7-hexachlorobicyclo-[2.2.1]hepta-2, 5-dien-2-ylmethyl benzoates

Doi:10.1134/S1070428010030036
(2010)
Asymmetric hydrogenation of methyl pyruvate in the continuous gas phase using Supported Ionic Liquid Phase (SILP) catalysis

Doi:10.1016/j.molcata.2013.04.022
(2013)
Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [³H]dopamine uptake at the vesicular monoamine transporter-2

Doi:10.1016/j.bmcl.2016.03.119
(2016)
Direct synthesis of 6-arylpurines by reaction of 6-chloropurines with activated aromatics

Doi:10.1021/jo1010334
(2010)

Article Doi