Non-oxidative Methodology for the Synthesis of Vinblastine and Vincristine Models

DOI: 10.1039/c39890000518

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 518 - 520 (1989)

Update date:2022-09-26

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Authors:

Magnus, Philip

Ladlow, Mark

Elliott, Jason

Kim, Chung Sook

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Article abstract of DOI:10.1039/c39890000518

Fragmentation of the tetracyclic amine (5), initiated by a chloroformate to give the putative iminium ion (6) in the presence of an aromatic nucleophile, provides convenient access to model bis-alkaloids such as (7)-(15).

Full text of DOI:10.1039/c39890000518

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