Development of a fully synthetic stereoselective route to 6-Deoxyerythronolide B by reiterative applications of the Lewis acid catalyzed diene aldehyde cyclocondensation reaction: A remarkable instance of diastereofacial selectivity

Article abstract of DOI:10.1021/jo00292a045

The synthesis of racemic 2, which contains the relative stereochemistry appropriate to a synthesis of (9S)-dihydro-6-deoxyerythronolide B (see compound 38), is described. The synthesis features three Lewis acid catalyzed diene aldehyde cyclocondensation r