The effects of in-situ trimethylsilyl chloride on the regioselectivity of the addition of α-alkoxy- and α-alkyl-substituted organocuprates to enals

Article abstract of DOI:10.1016/0022-328X(89)87349-8

The regioselectivity of the addition of α-substituted organocuprates to enals has been examined.The addition of trimethylsilyl chloride to both the enal and cuprate prior to the combination of the reactants improves the regioselectivity and the isolated y