Trans hydrindanes by dimide reduction: Synthesis of dihydro-B-nortestosterone and its 17α-methyl derivative

DOI: 10.1016/0040-4039(96)01328-7

Source and publish data:

Tetrahedron Letters p. 6221 - 6222 (1996)

Update date:2022-08-05

Topics:

Authors:

Kasal, Alexander

Chodounska, Hana

Szczepek, Wojciech J.

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Article abstract of DOI:10.1016/0040-4039(96)01328-7

Reductive hydroboration of Δ⁵-B-norsteroids (e.g., 1) affords 5α-dihydro products (e.g., 3) in a low yield. Better yields, were obtained by reduction with diimide. The method was employed in the synthesis of potential antiandrogens - 17β-hydroxy-B-nor-5α-androstan-3-one (8) and its 17α-methyl derivative (9).

Full text of DOI:10.1016/0040-4039(96)01328-7

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