Chemistry - A European Journal p. 2442 - 2446 (2019)
Update date:2022-08-05
Topics:
Ranjan, Prabhat
Ojeda, Gerardo M.
Sharma, Upendra K.
Van der Eycken, Erik V.
A metal-free, phosphine-catalyzed intramolecular “umpolung Michael addition” on alkynes to form spiroindol(en)ines is reported. This nucleophilic catalysis enables the formation of a wide scope of five- and six-membered spiroindol(en)ines in moderate to excellent yields in batch as well as under continuous-flow conditions. Triphenylphosphine-catalyzed nucleophilic activation of alkynes allows the exclusive formation of exo-product under mild reaction conditions.
View MoreCeresking Ecology & Technology co.,ltd
Contact:86 22 66218397
Address:Room 1613, Zheshang Mansion, No. 1988, Yingbin Avenue, Binhai New District, Tianjin,China.
Contact:+86-22-83718541
Address:32th Floor, Rongqiao Center Intersection of Changjiang Road and Nankai Six Road Nankai District Tianjin 300102, China
Changzhou Litong Chemical Co., Ltd.
website:http://www.litonchem.com/
Contact:+86-519-86301238
Address:Laoba Rd, Hutang town Changzhou Jiangsu
Jinhua City Mingzhu Pharmaceutical Co.,Ltd.
Contact:15857995878 0579-82207761
Address:No.169 Shenze Road, New Area,Jinpan Development Zone, Jinhua
Compro Shijiazhuang Fine Chemical Co., Ltd
Contact:0086-311-89689838
Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Doi:10.1016/j.tet.2011.12.055
(2012)Doi:10.1021/ol1013476
(2010)Doi:10.1016/j.tetlet.2017.09.076
(2017)Doi:10.1039/b926599f
(2010)Doi:10.1016/j.jfluchem.2010.01.006
(2010)Doi:10.1021/acs.orglett.8b01368
(2018)
