Bioorganic and Medicinal Chemistry Letters p. 1991 - 1996 (1998)
Update date:2022-08-03
Topics:
Augelli-Szafran, Corinne E.
Jaen, Juan C.
Moreland, David W.
Nelson, Carrie B.
Penvose-Yi, Jan R.
Schwarz, Roy D.
Our interest in the area of m4 muscarinic antagonists has led us to study a series of benzoxazine isoquinolines. One of the most potent and selective compounds of this series is example 1 with an IC50 value of 90.7nM at m4 receptors, and 72-fold (m1), 38-fold (m2), 10-fold (m3), and 82- fold (m5) more selective compared to the other receptors. The synthesis and receptor binding affinity of analogs of 1 are reported.
View MoreXinchang Jiu Xin Pharmaceutical Co., Ltd
website:http://www.jiuxinpharm.com
Contact:86 137 5756 8585
Address:Poyang industry Park
Wuhan Better Organic Technology Inc.
Contact:13307163183
Address:Wuhan Economic&Technology Development Zone, Hubei
Contact:86-510-82853889
Address:Rm.3732, No.18-2,Yonghe Rd.,Wuxi,Jiangsu,214023,China
Shuanghe Bio-Technology Limited(expird)
Contact:+86-571-61710758,18968016640
Address:Jinqiao north road 916# Fuyang
Shanghai HengXun Pharmaceutical Tech. Co., Ltd.
Contact:86-86-52730756
Address:Room 603, No. 240, Tianmuzhong Road, Zhabei, Shanghai, China
Doi:10.1248/cpb.53.256
(2005)Doi:10.1021/ma0115850
(2002)Doi:10.1016/0223-5234(89)90106-2
(1989)Doi:10.1016/j.tet.2010.05.051
(2010)Doi:10.1002/adsc.201500426
(2015)Doi:10.1139/v69-202
(1969)
