Bioorganic and Medicinal Chemistry Letters p. 1991 - 1996 (1998)
Update date:2022-08-03
Topics:
Augelli-Szafran, Corinne E.
Jaen, Juan C.
Moreland, David W.
Nelson, Carrie B.
Penvose-Yi, Jan R.
Schwarz, Roy D.
Our interest in the area of m4 muscarinic antagonists has led us to study a series of benzoxazine isoquinolines. One of the most potent and selective compounds of this series is example 1 with an IC50 value of 90.7nM at m4 receptors, and 72-fold (m1), 38-fold (m2), 10-fold (m3), and 82- fold (m5) more selective compared to the other receptors. The synthesis and receptor binding affinity of analogs of 1 are reported.
View Morechengdu firsterchem Pharmaceutical Co., Ltd.
Contact:028-66825849
Address:chengdu
Changzhou LanXu Chemical Co.,ltd.(expird)
Contact:86-0519-86330911,13656129734,15261186386
Address:Room 524, Depart.Chemical, Changzhou Science and Eductaion town, Jiangsu, China;Factory: Haian Fine Chemical Industry Park,Nantong,Jiangsu,China
Contact:13813902930 025-52714267
Address:20 Fengji Road, Yuhua Economic Development Zone, Nanjing, Jiangsu, P. R. China
Shandong Xinke Petrochemical Co., Ltd.
Contact:+86-546-7277016
Address:Gudao Industrial Park, Hekou District, Dongying, Shandong Province, China
HEZE KINGVOLT CHEMICAL CO., LTD
Contact:86-573-82118911
Address:Juancheng Industry Park
Doi:10.1248/cpb.53.256
(2005)Doi:10.1021/ma0115850
(2002)Doi:10.1016/0223-5234(89)90106-2
(1989)Doi:10.1016/j.tet.2010.05.051
(2010)Doi:10.1002/adsc.201500426
(2015)Doi:10.1139/v69-202
(1969)
