A short practical approach to 24R,25-dihydroxyvitamin D3

DOI: 10.1016/j.jsbmb.2010.03.071

Source and publish data:

Journal of Steroid Biochemistry and Molecular Biology p. 43 - 45 (2010)

Update date:2022-07-29

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Authors:

Nicoletti, Daniel

Gregorio, Carlos

Mourino, Antonio

Maestro, Miguel

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Article abstract of DOI:10.1016/j.jsbmb.2010.03.071

A synthesis of the vitamin D₃ metabolite 24R,25-dihydroxyvitamin D₃ (1) by Lythgoe's Wittig-Horner approach is described. The key step of the synthesis is the stereocontrolled introduction of the 24-hydroxyl group by a palladium(0)-induced [3,3]-sigmatropic rearrangement on a 22R-allylic acetate (7).

Full text of DOI:10.1016/j.jsbmb.2010.03.071

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