Preparation and Anticonvulsant Activity of a Series of Functionalized α-Aromatic and α-Heteroaromatic Amino Acids

Article abstract of DOI:10.1021/jm00165a006

We recently reported the potent anticonvulsant activity of (R,S)-α-acetamido-N-benzyl-α-phenylacetamide (2b).Selectively substituted derivatives of this compound have now been prepared (23 examples) and evaluated in the maximal electroshock seizure (MES)