Journal of Medicinal Chemistry p. 919 - 926 (1990)
Update date:2022-09-26
Topics: Amino acids Functionalized Preparation Experimental Anticonvulsant activity α-Aromatic α-Heteroaromatic
Kohn, Harold
Sawhney, Kailash N.
LeGall, Philippe
Conley, Judith D.
Robertson, David W.
Leander, J. David
We recently reported the potent anticonvulsant activity of (R,S)-α-acetamido-N-benzyl-α-phenylacetamide (2b).Selectively substituted derivatives of this compound have now been prepared (23 examples) and evaluated in the maximal electroshock seizure (MES)
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Doi:10.1002/jhet.5570260335
(1989)Doi:10.1055/s-1989-27251
(1989)Doi:10.1021/jm400241j
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(1990)