Synthesis and anticonvulsant activity of 2-benzylglutarimides

DOI: 10.1021/jm00165a007

Source and publish data:

Journal of Medicinal Chemistry p. 926 - 931 (1990)

Update date:2022-09-26

Topics:

Authors:

Goehring

Greenwood

Nwokogu Nwokogu

Pisipati

Rogers Rogers

Wolfe Wolfe

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Article abstract of DOI:10.1021/jm00165a007

A series of 2-benzylglutarimides (4) and their N-methyl analogues (5) were prepared according to the Topliss scheme for the selection of benzyl substituents to maximize anticonvulsant activity. A total of 22 such compounds were subjected to initial (phase

Full text of DOI:10.1021/jm00165a007

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