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11), 3.97 (s, 3H, CO2CH3), 3.82 (s, 3H, 40-OCH3), 3.68 (s, 6H, 30, 50-OCH3), 3.55–
3.58 (m, 1H, H-3), 3.22–3.27 (m, 1H, H-2); ESI-MS m/z (%): 639 ([M+NH4]+,
673.1431; found, 673.1429. Compound 8i: 60% yield, white solid, mp 115–
119 °C;
½
a 2D4
ꢁ
= ꢂ56.7 (c 3.0 mg/mL, CHCl3); 1H NMR (400 MHz, CDCl3) d:
100); HRMS-ESI: calcd for
C
31H31N2O13 ([M+NH4]+), 639.1821; found,
7.91(dd, J = 7.6, 1.2 Hz, 1H), 7.42–7.57 (m, 3H), 7.02 (s, 1H, H-5), 6.50 (s, 1H, H-
8), 6.29 (s, 2H, H-20, 60), 6.10 (d, J = 6.4 Hz, 1H, H-4), 5.95–5.98 (m, 2H, OCH2O),
5.38 (dd, J = 6.4, 4.4 Hz, 1H, NH), 4.51–4.56 (m, 2H, H-1, H-11), 4.23–4.28 (m,
1H, H-11), 3.92 (s, 3H, CO2CH3), 3.79 (s, 3H, 40-OCH3), 3.74 (s, 6H, 30, 50-OCH3),
2.99–3.06 (m, 1H, H-3), 2.90–2.95 (m, 1H, H-2); ESI-MS m/z (%): 576 ([M+H]+,
100); HRMS-ESI: calcd for C31H30NO10 ([M+H]+), 576.1864; found, 576.1870.
639.1826. Compound 8e: 79% yield, white solid, mp 96–99 °C; ½a D24
= ꢂ61 (c
ꢁ
4.1 mg/mL, CHCl3); 1H NMR (400 MHz, CDCl3) d: 7.75–7.77 (m, 1H), 7.61–7.64
(m, 1H), 7.54–7.57 (m, 2H), 7.05 (s, 1H, H-5), 6.56 (s, 1H, H-8), 6.36 (d,
J = 3.6 Hz, 1H, H-4), 6.30 (s, 2H, H-20, 60), 5.98 (dd, J = 9.6, 1.2 Hz, 2H, OCH2O),
4.67 (d, J = 5.2 Hz, 1H, H-1), 4.42–4.47 (m, 1H, H-11), 4.13–4.18 (m, 1H, H-11),
3.81 (s, 3H, CO2CH3), 3.80 (s, 3H, 40-OCH3), 3.75 (s, 6H, 30, 50-OCH3), 3.21–3.26
(m, 1H, H-3), 3.07–3.13 (m, 1H, H-2); EI-MS m/z (%): 576 (M+, 3); HRMS-ESI:
calcd for C31H32NO11 ([M+NH4]+), 594.1970; found, 594.1965. Compound 8f:
Compound 8j: 53% yield, light yellow, mp 177–178 °C; ½a D24
= ꢂ20 (c 1.0 mg/mL,
ꢁ
CHCl3); 1H NMR (400 MHz, CDCl3) d: 8.18–8.20 (m, 1H), 7.87–7.89 (m, 1H),
7.63 (t, J = 8.0 Hz, 1H), 6.84 (s, 1H, H-5), 6.59 (d, J = 7.2 Hz, 1H, H-4), 6.51 (s, 1H,
H-8), 6.26 (s, 2H, H-20, 60), 5.97–5.99 (m, 2H, OCH2O), 5.36 (dd, J = 7.6, 4.4 Hz,
1H, NH), 4.57 (d, J = 5.2 Hz, 1H, H-1), 4.44–4.48 (m, 1H, H-11), 3.92–3.97 (m,
4H, H-11, CO2CH3), 3.76 (s, 3H, 40-OCH3), 3.73 (s, 6H, 30, 50-OCH3), 2.98–3.04
(m, 1H, H-3), 2.89–2.94 (m, 1H, H-2); ESI-MS m/z (%): 621 ([M+H]+, 100);
76% yield, light yellow, mp 140–142 °C; ½a D24
ꢁ
= ꢂ114 (c 5.7 mg/mL, CHCl3); 1H
NMR (400 MHz, CDCl3) d: 8.39 (d, J = 8.4 Hz, 1H), 8.28 (d, J = 8.0 Hz, 1H), 7.70 (t,
J = 8.0 Hz, 1H), 6.89 (s, 1H, H-5), 6.60 (s, 1H, H-8), 6.37 (d, J = 3.2 Hz, 1H, H-4),
6.29 (s, 2H, H-20, 60), 6.00 (d, J = 6.8 Hz, 2H, OCH2O), 4.72 (d, J = 5.2 Hz, 1H, H-1),
4.38–4.42 (m, 1H, H-11), 3.87–3.95 (m, 1H, H-11), 3.80 (s, 3H, 40-OCH3), 3.75 (s,
9H, CO2CH3, 30, 50-OCH3), 3.25–3.30 (m, 1H, H-3), 3.07–3.11 (m, 1H, H-2); ESI-
MS m/z (%): 622 ([M+H]+, 100); HRMS-ESI: calcd for C31H31N2O13 ([M+NH4]+),
639.1821; found, 639.1816. Compound 8g: 59% yield, white solid, mp 205–
HRMS-ESI: calcd for
Compound 8k: 33% yield, white solid, mp 118–120 °C;
C
31H29N2O12 ([M+H]+), 621.1715; found, 621.1711.
½ ꢁ = ꢂ28.6 (c
a 2D4
1.4 mg/mL, CHCl3); 1H NMR (400 MHz, CDCl3) d: 8.02–8.04 (m, 1H), 7.84 (d,
J = 7.2 Hz, 1H), 7.54–7.71 (m, 6H), 6.92 (s, 1H, H-5), 6.56 (s, 1H, H-8), 6.47 (s,
2H, H-20, 60), 6.16 (d, J = 8.0 Hz, 1H, H-4), 5.98 (d, J = 2.0 Hz, 2H, OCH2O), 4.68–
4.71 (m, 2H, H-1, H-11), 4.33–4.38 (m, 1H, H-11), 3.85 (s, 3H, CO2CH3), 3.87 (s,
3H, CO2CH3), 3.68 (s, 6H, 30, 50-OCH3), 2.99–3.02 (m, 2H, H-2, H-3); ESI-MS m/z
(%): 742 ([M+NH4]+, 100); HRMS-ESI: calcd for C39H36NO14 ([M+NH4]+),
742.2130; found, 742.2136. Compound 8l: 49% yield, light yellow, mp 134–
207 °C; ½a 2D4
ꢁ
= ꢂ151.7 (c 2.9 mg/mL, CHCl3); 1H NMR (400 MHz, CDCl3) d: 7.87–
7.89 (m, 1H), 7.56–7.65 (m, 3H), 6.93 (s, 1H, H-5), 6.56 (s, 1H, H-8), 6.43 (s, 2H,
H-20, 60), 6.23 (d, J = 8.8 Hz, 1H, H-4), 5.99 (s, 2H, OCH2O), 4.80 (s, 1H, H-1),
4.62–4.74 (m, 2H, H-11), 3.83 (s, 3H, CO2CH3), 3.79 (s, 3H, 40-OCH3), 3.69 (s, 6H,
30, 50-OCH3), 3.26–3.32 (m, 1H, H-3); ESI-MS m/z (%): 611 ([M+H]+, 3); HRMS-
ESI: calcd for C31H31NO11Cl ([M+NH4]+), 628.1580; found, 628.1587. Compound
135 °C; ½a 2D4
ꢁ
= ꢂ64.3 (c 2.8 mg/mL, CHCl3); 1H NMR (400 MHz, CDCl3) d: 8.56–
8h: 60% yield, light yellow, mp 147–149 °C; ½a D24
ꢁ
= ꢂ96.6 (c 2.9 mg/mL, CHCl3);
8.58 (m, 1H), 8.39–8.42 (m, 2H), 8.30 (d, J = 7.6 Hz, 1H), 7.73 (t, J = 8.0 Hz, 2H),
6.85 (s, 1H, H-5), 6.60 (s, 1H, H-8), 6.50 (s, 2H, H-20, 60), 6.16 (d, J = 9.2 Hz, 1H,
H-4), 6.00–6.02 (m, 2H, OCH2O), 4.70 (d, J = 4.4 Hz, 1H, H-1), 4.46–4.50 (m, 1H,
H-11), 4.28–4.32 (m, 1H, H-11), 3.95 (s, 3H, CO2CH3), 3.88 (s, 3H, CO2CH3), 3.72
(s, 6H, 30, 50-OCH3), 2.93–3.06 (m, 2H, H-2, H-3); ESI-MS m/z (%): 832
([M+NH4]+, 100); HRMS-ESI: calcd for C39H34N3O18 ([M+NH4]+), 832.1832;
found, 832.1836.
1H NMR (400 MHz, CDCl3) d: 8.41 (d, J = 8.4 Hz, 1H), 8.31 (d, J = 7.6 Hz, 1H),
7.73 (t, J = 8.0 Hz, 1H), 6.88 (s, 1H, H-5), 6.60 (s, 1H, H-8), 6.47 (s, 2H, H-20, 60),
6.25 (d, J = 9.2 Hz, 1H, H-4), 6.01 (d, J = 10.8 Hz, 2H, OCH2O), 4.83 (s, 1H, H-1),
4.56–4.61 (m, 1H, H-11), 4.42–4.46 (m, 1H, H-11), 3.90 (s, 3H, CO2CH3), 3.79 (s,
3H, 40-OCH3), 3.76 (s, 6H, 30, 50-OCH3), 3.18–3.32 (m, 1H, H-3); ESI-MS m/z (%):
673 ([M+NH4]+, 100); HRMS-ESI: calcd for C31H30N2O13Cl ([M+NH4]+),