Bioorganic and Medicinal Chemistry Letters p. 4885 - 4891 (2010)
Update date:2022-09-26
Topics:
Liu, Hu
Kuhn, Cyrille
Feru, Frederic
Jacques, Suzanne L.
Deshmukh, Gayatri D.
Ye, Ping
Rennie, Glen R.
Johnson, Theresa
Kazmirski, Steven
Low, Simon
Coli, Rocco
Ding, Yuan-Hua
Cheng, Alan C.
Tecle, Haile
English, Jessie M.
Stanton, Robert
Wu, Joe C.
By targeting an extended region of the conventional 'DFG-out' pocket of p38α, while minimizing interactions with the specificity pocket and eliminating interactions with the adenine binding site, we are able to design and synthesize a number of pyrazole-u
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