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Crafts acylation.
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of the major stereogenic center over the total number of the minor center.
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Synthesis 2006, 2643–2645.
radiation (k = 0.71073 Å), 2072 unique [Rint = 0.049] used for struc-
ture solution (direct methods, SHELXS-9734) and refinement (full-
matrix least-squares on F2, SHELXL-9734) with 117 parameters and
3 restraint, H-atoms with a riding model (H(O) free), R1 (I
>2r(I)) = 0.040, wR2 (all data) = 0.100, S = 1.05, largest diff. peak
and hole 0.298 and À0.194 e ÅÀ3. The absolute configuration could
not be determined reliably by refinement of Flack’s x-parameter35
and calculation of Hooft’s FLEQ parameter36 (x = À1.2(13);
FLEQ = À0.9(6)).
Crystallographic data (excluding structure factors) for the struc-
tures reported in this work have been deposited with the Cam-
bridge Crystallographic Data Centre as supplementary
publication no. CCDC-772939 ((R,R)-12). Copies of the data can
be obtained free of charge on application to The Director, CCDC,
12 Union Road, Cambridge DB2 1EZ, UK (Fax: int.code+(1223)336
033; e-mail: deposit@ccdc.cam.ac.uk).
Acknowledgments
This work was supported by the Center for Functional Nano-
structures (CFN, C5.2.) and the BASF (donation of Me-CBS catalyst).
O. Plietzsch is a fellow of the Konrad-Adenauer-Stiftung. We thank
Dr. J. Bürck (KIT, Campus North, IBG) for the CD spectra recording,
Karolin Niessner for the HPLC analysis, and P. Groß for helpful
advice.
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