Synthesis p. 3361 - 3371 (2021)
Update date:2022-07-29
Topics: alkenes Carbon monoxide Tandem Intermolecular Palladium Catalysis Azides C-H Amidation
Gu, Zheng-Yang
Wu, Yang
Jin, Feng
Bao, Xiaoguang
Xia, Ji-Bao
An atom- and step-economic intermolecular multi-component palladium-catalyzed C-H amidation of alkenes with carbon monoxide and organic azides has been developed for the synthesis of alkenyl amides. The reaction proceeds efficiently without an ortho -directing group on the alkene substrates. Nontoxic dinitrogen is generated as the sole by-product. Computational studies and control experiments have revealed that the reaction takes place via an unexpected mechanism by tandem palladium catalysis.
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