RADIOIODINATION VIA VINYLSTANNYLATED ALKYLATING AGENTS

Article abstract of DOI:10.1016/S0040-4039(01)80462-7

p-Toluenesulfonate esters of (E)- and (Z)-3-(tri-n-butylstannyl)-2-propen-1-ol readily react with nucleophiles to give vinylstannanes which are substrates for rapid, efficient and stereospecific radioiododestannylation at the no-carrier-added level.This general approach is illustrated by syntheses of iodinated spiperone analogs for studies of dopamine D₂ receptors.