Enantiomerically pure and highly substituted alicyclic α,α- difluoro ketones: Potential inhibitors for malarial aspartic proteases, the plasmepsins

Article abstract of DOI:10.1002/ejoc.201000712

The design and synthesis of novel fluorinated building blocks is of major interest in the development of new pharmaceuticals and agrochemicals. A quantitative search in the Protein Data Bank (PDB) manifests the use of di- and trifluoro hydrates for bindin