Conjugates of betulin derivatives with AZT as potent anti-HIV agents

DOI: 10.1016/j.bmc.2010.06.092

Source and publish data:

Bioorganic and Medicinal Chemistry p. 6451 - 6469 (2010)

Update date:2022-09-26

Topics:

Authors:

Xiong, Juan

Kashiwada, Yoshiki

Chen, Chin-Ho

Qian, Keduo

Morris-Natschke, Susan L.

Lee, Kuo-Hsiung

Takaishi, Yoshihisa

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Article abstract of DOI:10.1016/j.bmc.2010.06.092

Fourteen novel conjugates of 3,28-di-O-acylbetulins with AZT were prepared as anti-HIV agents, based on our previously reported potent anti-HIV triterpene leads, including 3-O-acyl and 3,28-di-O-acylbetulins. Nine of the conjugates (49-53, 55, 56, 59, and

Full text of DOI:10.1016/j.bmc.2010.06.092

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