Pyrazolo[3,4-d]pyrimidines related to lonidamine

Article abstract of DOI:10.1002/jhet.5570260319

This paper describes the synthesis of several pyrazolo[3,4-d]pyrimidines and tricyclic compounds with an imidazole, triazole or tetrazole ring fused to the pyrazolo[3,4-d]pyrimidine ring system, in an angular position (C-4 and N-5). All compounds reported herein contain the same substituent as 'Lonidamine', namely the 2,4-dichlorobenzyl group, attached to the pyrazole nucleus.