Bioorganic and Medicinal Chemistry Letters p. 5514 - 5520 (2010)
Update date:2022-08-02
Topics:
Rehman, Abdul
Soni, Ajay
Naik, Keshav
Nair, Sreeji
Palle, Venkata P.
Dastidar, Sunanda
Ray, Abhijit
Alam
Salman, Mohammad
Cliffe, Ian A.
Sattigeri, Viswajanani
A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities.
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(2010)