Heterocycles p. 844 - 856 (2016)
Update date:2022-09-26
Topics:
Kobayashi, Kazuhiro
Shigemura, Yuuho
Tanmatsu, Miyuki
A convenient method for the synthesis of N,N-disubstituted 1-aryl-1,3-dihydro-2H-isoindole-2-carbothioamides starting from 2-[aryl(methoxy)methyl]phenyl bromides is described. Thus, the reaction of 1-[aryl(methoxy)methyl]-2-(isothiocyanatomethyl)benzenes, derived from the starting materials by an easily operated five-step sequence under mild conditions, with secondary amines provides the corresponding thiourea derivatives, which cyclize on treatment with methanesulfonic acid to afford the desired products.
View Morewebsite:http://www.cheminn.com/
Contact:86-531-67875205
Address:No.9-2,South of Shanda Road, Jinan ,China
Nanjing Fayekong Chemcial Co.,Ltd(expird)
Contact:86-25-58813444
Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China
ALPHA PHARMACEUTICAL CO,LTD JIANGSU
Contact:+86-527-84829968,+86-527-84829998
Address:suqian city
Hubei Xinghuo Chemical Co., Ltd.,
Contact:13925817279 13907299441
Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China
XI'AN CHUKANG BIOTECHNOLOGY CO.,LTD
Contact:29-63685658 63685359
Address:Room 3-1202,Building 1,Oriental oasis,East of Xianning Road,Xi'an,Shaanxi 710043 P.R.China
Doi:10.1016/S0031-9422(00)86094-X
(1967)Doi:10.1021/ol102292a
(2010)Doi:10.1002/pola.24346
(2010)Doi:10.1002/chem.201901826
(2019)Doi:10.1002/anie.201911025
(2019)Doi:10.1002/ejic.200901208
(2010)