
Bioorganic and Medicinal Chemistry Letters p. 4077 - 4079 (2010)
Update date:2022-08-03
Topics:
Pototschnig, Gerit
De Csaky, Christian Morales
Montenegro Burke, Jose R.
Schitter, Georg
Stuetz, Arnold E.
Tarling, Chris A.
Withers, Stephen G.
Wrodnigg, Tanja M.
Biotin-iminosugar conjugates of different configuration such as d-gluco, d-galacto, l-ido as well as a furanoid representative in the d-manno configuration have been synthesised and exhibit powerful inhibition of β-glucosidase from Agrobacterium sp. with Ki values in the range of the respective parent compounds. Such molecular probes have potential for activity-based protein profiling taking advantage of the biotin-(strept)avidin interaction.
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Doi:10.1016/j.ejmech.2010.08.064
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